Regulation of Translation in the Protozoan Parasite Leishmania

Protozoan Parasite Leishmania donovani

Regulation of intracellular calcium in promastigotes of the human protozoan parasite Leishmania donovani.

By using the fluorescent Ca2+ indicator fura 2, we show that the concentration of free calcium in the cytoplasm of Leishmania donovani promastigotes is maintained at very low levels (73.5 +/- 10-94 +/- 8 nM at a [Ca2+]i range of 0-1 mM). The maintenance of low [Ca2+]i is energy-dependent as it is disrupted by KCN, H+-ATPase inhibitors, and ionophores. KCN, nigericin, and N,N'-dicyclohexylcarbod...

Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin.

A critical step in the infectious cycle of Leishmania is the differentiation of parasites within the sand fly vector to the highly infective metacyclic promastigote stage. Here, we establish tetrahydrobiopterin (H4B) levels as an important factor controlling the extent of metacyclogenesis. H4B levels decline substantially during normal development, and genetic or nutritional manipulations showe...

the translators agency and ideological manipulation in translation: the case of political texts in translation classes in iran

در این تحقیق به نقش واسطه ای مترجم در ایجاد تغییرات ایدئولوژیک در ترجمه متون سیاسی پرداخته شده است. بدین منظور محقق متنی سیاسی در خصوص ادعاهای آمریکا در مورد برنامه هسته ای ایران را انتخاب کرد. این متن از سایت spacewar.com انتخاب شد که دارای ایدئولوژی مغرضانه در مورد برنامه هسته ای ایران است. سپس یک گروه 30 نفره از دانشجویان کارشناسی ارشدرشته مترجمی زبان انگلیسی دانشگاه شیخ بهایی انتخاب شدند. ا...

investigating the integration of translation technologies into translation programs in iranian universities: basis for a syllabus design in translation technology

today, information technology and computers are indispensable tools of any profession and translation technologies have become an indispensable part of translator’s workstation. with the increasing demands for high productivity and speed as well as consistency and with the rise of new demands for translation and localization, it is necessary for translators to be familiar with market demands an...